Basics of Ecstasy

1 January 2017

N-methamphetamine (MDMA), otherwise known as “ecstasy” is a “psychedelic amphetamine” that has gained popularity the past twenty years because of the feelings of comfort, empathy, and connection to others it provides for the user. MDMA is considered an illicit substance in the United States, as it is in most other countries. MDMA was first synthesized in the 1890s, and it wasn’t until the 1970s and ‘80s that it was used as a psychotherapeutic tool and also started to become available on the street.

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Its growing popularity resulted in it being made illegal in the United States in 1985; since then the drug’s popularity has continued to increase. The issue of MDMA’s neurotoxicity is very complex, including debate about what constitutes neurotoxicity, but almost all experts now agree that MDMA is a neurotoxin. Keywords: MDMA, Ecstasy, XTC, neurotoxin, illegal, amphetamine, psychedelic MDMA most frequently comes in tablet form, although it is also found in capsules or as a powder. It is most commonly used orally and rarely snorted.

MDMA use is usually associated with the rave scene throughout the world, but was also used by therapists in experimental psychotherapy. Ecstasy’s demand usually exceeds supply, which creates the opening for certain individuals to sell virtually anything as “ecstasy”. This is why ecstasy pills are notoriously unreliable in content, more so than most other street drugs. The most common substitutes for MDMA are caffeine, ephedrine, amphetamines, MDA, MDE and DXM. (Julie Holland, 2001) A standard oral dose of MDMA is between 80 – 150 mg.

Most good quality pills contain somewhere in this range, generally 80 – 120 mg. A large percentage of users find that there is a “sweet spot” in MDMA dosage. Once this spot is found, higher dosages are not particularly desirable as they do not increase the sought after effects or duration. (Julie Holland, 2001) MDMA is criminalized in most countries in the world under a United Nations agreement, and its possession, manufacture or sale may result in criminal prosecution, not including exceptions made for scientific and medical research.

After the illegalization of MDMA, drugs such as 2CB were synthesized as a way around the legislation. Drugs such as this were chemically similar, and produced similar effects. In some countries, such as Germany, this works as a loophole to delay the illegalization of a drug and its variants. Although in the US, any new drug which has been designed to avoid the law is automatically prohibited. (World Drug Report, 2008) There has been much debate about the risk of MDMA, specifically the possibility of neurotoxic damage to the central nervous system.

The Multidisciplinary Association for Psychedelic Studies released the following statement in October 2008, “We found the low doses of MDMA (between 50 and 75 mg) were both psychologically and physiologically safe for all the subjects. Future studies in large samples and using larger doses are needed in order to further clarify the safety and efficacy of MDMA in the clinical setting in subjects with PTSD. ” (Ruse, Jerome, Mithoefer, Doblin, & Gibson, 2008). Like any drug, MDMA produces a plethora of effects, both positive and negative.

Among the positive effects are a mild to extreme mood lift, also known as euphoria, increased willingness to communicate, increase in energy, decreased fear and anxiety, feelings of love and empathy, forgiveness of self and others, increased awareness and appreciation of music, and an increased pleasure from the sense of touch. (Stillman R. , 1978) Neutral effects include appetite loss, visual distortion, nystagmus, mild visual hallucinations (uncommon), moderately increased heart rate and blood pressure, restlessness, and change in body temperature regulation. (Stillman R. 1978)

Negative side effects are inappropriate and/or unintended emotional bonding, anxiety, paranoia, agitation, tendency to say things you might feel uncomfortable about later, mild to extreme jaw clenching, tongue and cheek chewing, teeth grinding, difficulty concentrating, problems with activities requiring linear focus, short term memory loss, muscle tension, insomnia, erectile dysfunction, hyponatremia, nausea, headaches, and vertigo. These are effects that are very rarely experienced with low to moderate use, but can been seen with higher doses and frequent use. (Stillman R. 1978)

The above listed effects are uncommon, but possible negative effects experienced while on the drug. The “comedown” or “hangover” experienced the days after MDMA usage are far more common and are usually experienced after each usage. Although, like the negative effects, at higher doses and frequent use the hangover effects become increasingly worse. The most common after-effect is mild depression and/or fatigue lasting up to a week. A more uncommon effect, although reported, is a severe depression and/or fatigue. Ecstasy, like many other drugs, can be very harmful if abused.

Studies have shown a positive correlation between long time chronic users and depression. An article by Professor David Nutt published in the Journal of Psychopharmacology shed light on the lack of a balanced risk assessment in public discussions of MDMA(D. Nutt, 2009): “The general public, especially the younger generation, are disillusioned with the lack of balanced political debate about drugs. This lack of rational debate can undermine the trust in government in relation to drug misuse and thereby undermining the government’s message in public information campaigns.

The media in general seem to have an interest in scare stories about illicit drugs, though there are some exceptions (Horizon, 2008). A telling review of 10-year media reporting of drug deaths in Scotland illustrates the distorted media perspective very well (Forsyth, 2001). During this decade, the likelihood of a newspaper reporting a death from paracetamol was 1 per 250 deaths, for diazepam it was 1 in 50, whereas for amphetamine it was 1 in 3 and for ecstasy every associated death was reported. ”

A British study, taking account of the number of users, estimated that 0. per 10000 users of ecstasy result in death (Gore, 1999). Many theorize that the current way society deals with drugs could have a negative effect on the amount of deaths caused by ecstasy. Most anti-drug campaigns explain reasons why you should not do the drug, but very little information is available about what to do to stay safe while on the drug.

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