Chemical Synaptic Transmission

8 August 2016

You have just observed that each action potential in a burst can trigger additional neurotransmitter release. If calcium ions are removed from the extracellular solution, what will happen to neurotransmitter release at the axon terminal? Your answer : d. There will be no neurotransmitter release. Predict Question 2: What will happen to neurotransmitter release when low amounts of calcium are added back to the extracellular solution? Your answer : b. Neurotransmitter release will increase a small amount.

Predict Question 3: What will happen to neurotransmitter release when magnesium is added to the extracellular solution? Your answer : b. There will be less neurotransmitter release than in the control solution. Stop & Think Questions: Why does the stimulus intensity affect the amount of neurotransmitter release at the axon terminal? You correctly answered: d. Both a and b are correct. Why is there no neurotransmitter release from the axon terminal when there are no calcium ions in the extracellular solution? You correctly answered: c.

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Exocytosis of the synaptic vesicles is calcium dependent. Why did the high intensity stimulation fail to trigger the same amount of neurotransmitter release in the presence of extracellular Mg2+ as in the control extracellular solution? You correctly answered: a. Mg2+ blocks the calcium channels in the axon terminal. You scored 100% by answering 4 out of 4 questions correctly. 1. How is the neurotransmitter stored in the axon terminal before it is released? You correctly answered: c. contained in synaptic vessicles 2. Are neurotransmitter molecules released one at a time or in packets?

You correctly answered: b. in packets 3. With the normal extracellular calcium concentration, [Ca2+ ], when the action potential reaches the axon terminal it triggers You correctly answered: b. release of neurotransmitter by exocytosis. 4. Comparing the low intensity stimulus to the high intensity stimulus, the high intensity stimulus causes You correctly answered: b. more synaptic vesicles to undergo exocytosis When the stimulus intensity is increased, what changes: the number of synaptic vesicles released or the amount of neurotransmitter per vesicle?

Your answer: amount of neurotransmitters per vesicles 2. What happened to the amount of neurotransmitter release when you switched from the control extracellular fluid to the extracellular fluid with no Ca2+ ? How well did the results compare with your prediction? Your answer: There was no reaction and i said there would be no reaction because the reaction in Ca dependent. 3. What happened to the amount of neurotransmitter release when you switched from the extracellular fluid with no Ca2+ to the extracellular fluid with low Ca2+ ?

How well did the results compare with your prediction? Your answer: Neurotransmitter release will increase a small amount and that is what i said. 4. How did neurotransmitter release in the Mg2+ extracellular fluid compare to that in the control extracellular fluid? How well did the result compare with your prediction? Your answer: There was a small amount of amount of release and that is what I said. 5. How does Mg2+ block the effect of extracellular calcium on neurotransmitter release? Mg blocks the calcium channels in the axon terminals

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