# Nail Patella Syndrome

7 July 2016

1. Explain what must happen in order for Greg and Susan to have a child with O type blood and nail-patella syndrome. Greg needs to pass down his chromosome 9 which carry the alleles, n and i. Susan also has the n and I alleles on chromosome 9. If both these alleles from both parents are passed down, it will create the allele Nnii which produced the blood type O and nail patella syndrome.

2. Determine all possible parental and recombinant gametes produced by Greg and Susan. Gregâ€™s parental gametes are NI^ and ni; Gregâ€™s recombinant gametes are nI^A and Ni Susanâ€™s parental gametes are nI^B and Ni; Susanâ€™s recombinant gametes are NI^B and ni 3. Determine the frequency of each type of gamete.**

From the case study, we see that the dominant nail- patella trait resides on chromosome and is 10 recombination map units from the I gene. Knowing this information you need to divide 10 by 2 which produces 5.

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This means that the frequency of recombinant gametes is 5%. To find the parental gametes I took 100 and subtracted 10. Making 90 which is then divided by two (for two parental gametes). This produces 45 which means that both Susan and Gregâ€™s frequency of parental gametes are 45%. 4. Determine the probability of Greg and Susan having a child with nail-patella syndrome and O type blood.**

From the four outcomes: NI^AnI^B, ninI^B, NI^ANi, niNi we come to the conclusion that there is only a 25% chance that Greg and Susan will have a child with nail-patella syndrome and O blood type. We know this because niNI is the only outcome that shows a child with both items. 5. Identify one other condition associated with chromosome 9 and give a brief explanation of it. Another condition associated with chromosome 9 is 9q22.3 microdeletion. This disorder causes seizures occasionally, intellectual disability, physical abnormalities, and delayed development, especially a delay in motor skills (sitting, standing, walking) in individuals. In many the people, the delays are temporary improve and improve as one gets older. This disorder is caused from a deletion of a small piece of chromosome, the q22.3 region (containing at least 270 genes). The affected individual can also have an increased chance of developing tumors and cancer.

Source:
http://ghr.nlm.nih.gov/condition/9q223-microdeletion

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